Shunji Sugawara Selected Research

Clodronic Acid (Clodronate)

1/2019	Augmentation of Lipopolysaccharide-Induced Production of IL-1α and IL-1β in Mice Given Intravenous Zoledronate (a Nitrogen-Containing Bisphosphonate) and Its Prevention by Clodronate (a Non-nitrogen-containing Bisphosphonate).
1/2017	Underlying Mechanisms and Therapeutic Strategies for Bisphosphonate-Related Osteonecrosis of the Jaw (BRONJ).
1/2017	Inflammatory Effects of Nitrogen-Containing Bisphosphonates (N-BPs): Modulation by Non-N-BPs.
1/2016	The Bisphosphonates Clodronate and Etidronate Exert Analgesic Effects by Acting on Glutamate- and/or ATP-Related Pain Transmission Pathways.
10/2013	Inhibition of phosphate transporters ameliorates the inflammatory and necrotic side effects of the nitrogen-containing bisphosphonate zoledronate in mice.
1/2013	Analgesic effects of the non-nitrogen-containing bisphosphonates etidronate and clodronate, independent of anti-resorptive effects on bone.
12/2012	Prime role of bone IL-1 in mice may lie in emergency Ca(2+)-supply to soft tissues, not in bone-remodeling.
5/2009	Necrotic actions of nitrogen-containing bisphosphonates and their inhibition by clodronate, a non-nitrogen-containing bisphosphonate in mice: potential for utilization of clodronate as a combination drug with a nitrogen-containing bisphosphonate.
10/2005	Comparative appraisal of clodronate, aspirin and dexamethasone as agents reducing alendronate-induced inflammation in a murine model.

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Shunji Sugawara Research Topics

Disease

15	Inflammation (Inflammations) 01/2021 - 10/2002
10	Hypersensitivity (Allergy) 01/2020 - 10/2007
6	Infections 01/2022 - 10/2007
6	Shock 02/2017 - 03/2005
5	Necrosis 01/2019 - 05/2009
5	Anaphylaxis (Anaphylactic Shock) 02/2017 - 03/2006
5	Bone Resorption 01/2017 - 01/2013
5	Osteonecrosis (Kienbock's Disease) 01/2016 - 05/2009
5	Osteoporosis 01/2016 - 04/2010
5	Periodontitis 03/2007 - 10/2002
3	Pain (Aches) 01/2017 - 01/2016
3	Chronic Periodontitis 01/2014 - 11/2005
3	Hepatitis 10/2011 - 08/2009
2	Squamous Cell Carcinoma (Epidermoid Carcinoma) 01/2021 - 06/2013
2	Biotin deficiency 01/2020 - 04/2008
2	Temporomandibular Joint Disorders (Temporomandibular Joint Disorder) 01/2016 - 12/2013
2	Bacterial Infections (Bacterial Infection) 01/2014 - 11/2005
2	Bruxism 12/2013 - 01/2012
2	Respiratory Distress Syndrome (Acute Respiratory Distress Syndrome) 03/2012 - 03/2005
2	Splenomegaly 02/2007 - 10/2005
1	Squamous Cell Carcinoma of Head and Neck 01/2021
1	Obesity 01/2018
1	Contact Dermatitis (Eczema, Contact) 01/2017
1	Osteoarthritis 01/2016
1	Hyperglycemia 05/2014
1	Cardiovascular Diseases (Cardiovascular Disease) 05/2014
1	Hypertension (High Blood Pressure) 05/2014
1	Tooth Loss 01/2014

Drug/Important Bio-Agent (IBA)

13	LipopolysaccharidesIBA 01/2021 - 03/2005
12	Diphosphonates (Bisphosphonates)IBA 01/2021 - 10/2005
9	Histamine (Histamine Dihydrochloride)FDA Link 10/2019 - 10/2005
9	Clodronic Acid (Clodronate)IBA 01/2019 - 10/2005
9	Etidronic Acid (HEDP)FDA LinkGeneric 01/2017 - 04/2010
8	Interleukin-1 (Interleukin 1)IBA 01/2021 - 08/2009
7	NickelIBA 01/2020 - 05/2009
6	NitrogenIBA 01/2021 - 04/2010
6	CytokinesIBA 01/2021 - 06/2003
6	EnzymesIBA 10/2019 - 10/2005
4	MetalsIBA 01/2020 - 05/2009
4	Histidine DecarboxylaseIBA 10/2019 - 02/2007
4	Analgesics (Analgesic Drugs)IBA 01/2017 - 01/2013
4	Zoledronic Acid (Zometa)FDA Link 10/2013 - 05/2009
3	Biotin (Vitamin H)FDA Link 01/2020 - 04/2008
3	Pharmaceutical PreparationsIBA 05/2014 - 03/2005
3	MannansIBA 11/2011 - 12/2009
3	Peptides (Polypeptides)IBA 10/2011 - 07/2006
3	Concanavalin AIBA 10/2011 - 07/2006
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2009 - 08/2007
3	Myeloblastin (Proteinase 3)IBA 03/2007 - 09/2004
3	Proteins (Proteins, Gene)FDA Link 03/2007 - 01/2005
2	Adenosine Triphosphate (ATP)IBA 01/2021 - 01/2016
2	InterleukinsIBA 01/2021 - 12/2013
2	Interleukin-6 (Interleukin 6)IBA 01/2021 - 01/2012
2	Phosphate Transport Proteins (Phosphate Transporter)IBA 01/2021 - 01/2017
2	AllergensIBA 01/2020 - 09/2013
2	Histamine H1 Receptors (Histamine H1 Receptor)IBA 10/2019 - 01/2012
2	Klebsiella O3 lipopolysaccharideIBA 02/2017 - 03/2006
2	Interleukin-18 (Interleukin 18)IBA 01/2014 - 08/2008
2	LigandsIBA 05/2012 - 03/2012
2	Platelet Activating FactorIBA 03/2012 - 12/2009
2	Serotonin (5 Hydroxytryptamine)IBA 09/2011 - 03/2006
2	Transaminases (Aminotransferases)IBA 09/2011 - 08/2009
2	AntigensIBA 06/2010 - 10/2007
2	Durapatite (Hydroxylapatite)IBA 05/2010 - 05/2009
2	Complement System Proteins (Complement)IBA 12/2009 - 03/2006
2	Alendronate (Alendronate Sodium)FDA LinkGeneric 05/2009 - 10/2005
2	LactoferrinIBA 03/2007 - 07/2006
2	Leukocyte Elastase (Neutrophil Elastase)IBA 03/2007 - 01/2005
2	Cathepsin GIBA 03/2007 - 01/2005
2	Serine Proteases (Serine Protease)IBA 01/2005 - 06/2003
1	Plasminogen Activator Inhibitor 1IBA 01/2022
1	Purinergic Receptors (Receptors, Purine)IBA 01/2021
1	Purinergic P2X7 ReceptorsIBA 01/2021
1	Amino Acids FDA Link 01/2020
1	SulfurIBA 01/2020
1	A-factor (Streptomyces)IBA 01/2019
1	Adrenergic Agents (Adrenergic Drugs)IBA 02/2017
1	CatecholaminesIBA 02/2017
1	Complement C5 (Complement 5)IBA 02/2017
1	hydroquinone (Esoterica)FDA Link 01/2017
1	Foscarnet FDA LinkGeneric 01/2017
1	diphosphoric acid (pyrophosphoric acid)IBA 01/2017
1	Pyrilamine (Mepyramine)FDA Link 01/2016
1	Chlorpheniramine (Chlorphenamine)FDA LinkGeneric 01/2016
1	Diphenhydramine (Benadryl)FDA LinkGeneric 01/2016
1	Flurbiprofen (Froben)FDA LinkGeneric 01/2016
1	Glutamic Acid (Glutamate)FDA Link 01/2016
1	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 01/2016
1	Indomethacin (Indometacin)FDA LinkGeneric 01/2016
1	titanium nickelide (Ni-Ti)IBA 01/2016
1	Glucagon-Like Peptide 1 (GLP 1)IBA 05/2014
1	Liraglutide FDA Link 05/2014
1	Epinephrine (Adrenaline)FDA LinkGeneric 05/2014
1	PowdersIBA 05/2014
1	Blood Glucose (Blood Sugar)IBA 05/2014
1	Norepinephrine (Noradrenaline)FDA LinkGeneric 05/2014
1	CorticosteroneIBA 05/2014

Therapy/Procedure

3	Intravenous Injections 12/2009 - 03/2005
2	Drug Substitution 05/2010 - 05/2009
1	Immunomodulation 01/2018